January
- January 11 – The first issue of Look magazine goes on sale in the United States.
- January 19 – Howard Hughes sets a new record by flying from Los Angeles to New York City in 7 hours, 28 minutes and 25 seconds.
- January 20 – Chief Justice Charles Evans Hughes swears in Franklin D. Roosevelt for a second term. This is the first time Inauguration Day in the United States occurs on that date, on which it has occurred ever since; the change is due to the ratification in 1933 of the 20th amendment to the U.S. Constitution.
- January 26 – The U.S. state of Michigan celebrates its Centennial Anniversary of statehood.
- January 31 - The Ohio River floods.
February
- February 5 – U.S President Franklin D. Roosevelt proposes a plan to enlarge the Supreme Court of the United States.
- February 11 – A sit-down strike ends when General Motors recognizes the United Automobile Workers Union.
- February 16 – Wallace H. Carothers receives a patent for nylon.
March
- March – The first issue of the comic book Detective Comics is published in the United States. Twenty-seven issues later, Detective Comics introduces Batman. The comic goes on to become the longest continually published comic magazine in American history; it is still published as of 2010.
- March 17 – The Atherton Report (private investigator Edwin Atherton's report detailing vice and police corruption in San Francisco) is released.
- March 18 – In the worst school disaster in American history in terms of lives lost, the New London School in New London, Texas suffers a catastrophic natural gas explosion, killing in excess of 295 students and teachers.
- March 19 – Mother Frances Hospital opens in Tyler, Texas in response to the New London School explosion.
- March 21 – The first successful flying car, Waldo Waterman's Aerobile, makes its initial flight.
- March 26
- In Crystal City, Texas, spinach growers erect a statue of the cartoon character Popeye.
- William Henry Hastie becomes the first African-American appointed to a federal judgeship .
April
- April 1 – Aden becomes a British crown colony.
- April 12 – NLRB v. Jones & Laughlin Steel: The Supreme Court of the United States rules that the National Labor Relations Act is constitutional.
- April 17 – The animated short Porky's Duck Hunt, directed by Tex Avery for the Looney Tunes series, featuring the debut of Daffy Duck, is released.
May
- May - 17 million unemployed in the USA.
- May 6 – Hindenburg disaster: In the United States, the German airship Hindenburg bursts into flame when mooring to a mast in Lakehurst, New Jersey. Of the 36 passengers and 61 crew on board, 13 passengers and 22 crew die, as well as one member of the ground crew
- May 27 – In California, the Golden Gate Bridge opens to pedestrian traffic, creating a vital link between San Francisco and Marin County. The next day, President Franklin D. Roosevelt pushes a button in Washington, D.C., signaling the start of vehicle traffic over the Golden Gate Bridge.
- May 30 - The Chicago Police Department shoot and kill ten unarmed demonstrators in Chicago in what is known as the Memorial Day massacre.
June
- June 14 – Pennsylvania becomes the first (and only) of the United States to celebrate Flag Day officially as a state holiday.
- June 28 – Civilian Conservation Corps (CCC) established in the United States, superseding the Emergency Conservation Work program.
July
- July 2
- Amelia Earhart and navigator Fred Noonan disappear after taking off from New Guinea during Earhart's attempt to become the first woman to fly around the world.
- A guard takes his place at the Tomb of the Unknowns in Washington, DC; continuous guard has been maintained there ever since.
- July 22 – New Deal: The United States Senate votes down President Franklin D. Roosevelt's proposal to add more justices to the Supreme Court of the United States.
- July 24 – Alabama drops rape charges against the so-called Scottsboro Boys.
August
- August 2 – The Marihuana Tax Act Pub. 238, 75th Congress, 50 Stat. 551 (Aug. 2, 1937), is a significant bill on the path that will lead to the criminalization of cannabis. It was introduced to U.S. Congress by Commissioner of the Federal Bureau of Narcotics, Harry Anslinger. (The Act is now commonly referred to using the modern spelling as the 1937 Marijuana Tax Act.)
September
- September 7 – CBS broadcasts a two-and-a-half hour memorial concert nationwide on radio in memory of George Gershwin, live from the Hollywood Bowl. Many celebrities appear, including Oscar Levant, Fred Astaire, Otto Klemperer, Lily Pons, and members of the original cast of Porgy and Bess. The concert is recorded and released complete years later in what is excellent sound for its time, on CD. The Los Angeles Philharmonic is the featured orchestra.
- September 17 – Abraham Lincoln's head is dedicated at Mount Rushmore.
- September 26 – Street and Smith Publications launches a half-hour radio program , The Shadow, with Orson Welles in the title role.
October
- October 1
- The Marihuana Tax Act becomes law in the United States.
- U.S. Supreme Court associate justice Hugo Black, in a nationwide radio broadcast, refutes allegations of past involvement in the Ku Klux Klan.
- October 5 – Roosevelt gives his famous Quarantine Speech in Chicago.
- October 15 – Ernest Hemingway's novel To Have and Have Not is first published.
November
- November 3 – Underdog Maurice J. Tobin resoundingly defeats former governor and mayor James Michael Curley in a Boston mayoral election that shocks the political establishment.
December
- December 12 - Mae West makes a risque guest appearance on the NBC Chase and Sanborn Hour that eventually results in her being banned from radio.
- December 21 – Walt Disney's Snow White and the Seven Dwarfs, the first feature-length animated cartoon with sound, opens in Los Angeles. By the end of its original run, it will earn over $8 million in international box office receipts.
- December 25 – At the age of 70, legendary conductor Arturo Toscanini conducts the NBC Symphony Orchestra on radio for the first time, beginning his successful 17-year tenure with that orchestra. This first concert consists of music by Vivaldi (at a time when he was still seldom played), Mozart, and Brahms. Millions tune in to listen, including U.S. President Franklin Delano Roosevelt.
Undated
- Jimmie Angel lands his plane on top of Devil's Mountain; however, the plane gets damaged and he has to trek through the rainforest for help.
- Of Mice and Men by John Steinbeck is published.
Ongoing
March
- In Crystal City, Texas, spinach growers erect a statue of the cartoon character Popeye.
- William Henry Hastie becomes the first African-American appointed to a federal judgeship .
April
June
July
- Amelia Earhart and navigator Fred Noonan disappear after taking off from New Guinea during Earhart's attempt to become the first woman to fly around the world.
- A guard takes his place at the Tomb of the Unknowns in Washington, DC; continuous guard has been maintained there ever since.
August
October
- The Marihuana Tax Act becomes law in the United States.
- U.S. Supreme Court associate justice Hugo Black, in a nationwide radio broadcast, refutes allegations of past involvement in the Ku Klux Klan.
December
Undated
Ongoing